STATISTICSMore than sample size determination and result calculation CRS is able to provide full-service support through all phases of clinical development, with an emphasis on Early Phase expertise. To this end, CRS rely, when necessary, on a resilient and trustful collaboration with highly experienced external statisticians. Whenever comprehensive statistics support is needed: Think CRS CRS successfully handles clinical trial projects of all sizes, ranging from small first-in-human (FIH) to larger proof-of-concept (POC) studies, e.g., it renders clinical development plans and/or individual study protocols, including study design, sample size determination, delineation of objectives and endpoints, as well as analysis strategies. Our statisticians, who have extensive experience with clinical trials, can provide all relevant services encompassing:• Statistics consulting• Data integration and standardization by approved CDISC standards: Study Data Tabulation Model (SDTM) and Analysis Data Model (ADaM) standardized formats• Complex study designs – Adaptive and Bayesian designs• Study protocol support and writing of statistical analysis plans• Regulatory submission support• Publications All in all, CRS offers comprehensive support for clinical development projects by leveraging technical expertise and efficiency in the implementation. REACHING OUT IS EASY AND FAST – LET’S TALK Prof. Dr. Thomas Forst Chairman of the Executive Boardlocated at CRS Mannheim LET’S TALK SCIENCE *protected email*+49 621 150 45 – 0 Dr. Marc Hetzel VP & Head of Business Developmentlocated at CRS Management LET’S TALK BUSINESS *protected email*+49 621 150 45 – 0 CRO Leadership Awards 2019 CRS is proud to be recognised again by pharma companies worldwide as a leading CRO with regard to: capabilities, compatibility, quality and reliability. European Biotechnology Guide Find CRS’s company profile in the European Biotechnology Science Industry Guide, volume 9 2019. EcoVadis – CSR Rating Based on the CSR rating by EcoVadis in 2022 CRS has been granted Silver Recognition Level.