tolerability Archives - CRS. Experts. Early Phase.

Efficacy and safety of the ghrelin-O-acyltransferase inhibitor BI 1356225 in overweight/obesity: Data from two Phase I, randomised, placebo-controlled studies.

Science 25. Mai 2023

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Pharmacokinetics, pharmacodynamics, and safety of BAY 2433334, a novel activated factor XI inhibitor, in healthy volunteers: A randomized phase 1 multiple-dose study.

Science 27. Januar 2023

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Pharmacological profile, efficacy and safety of lixisenatide in type 2 diabetes mellitus.

Science 21. November 2022

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First published in Expert Opinion on Pharmacotherapy on 2013 Nov. Expert Opin Pharmacother. 2013 Nov;14(16):2281-96. doi: 10.1517/14656566.2013.838559. Epub 2013 Oct...

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Multiple-dose tolerability, pharmacokinetics, and pharmacodynamics of ponesimod, an S1P1 receptor modulator: favorable impact of dose up-titration.

Science 21. November 2022

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First published in The Journal of Clinical Pharmacology on 2014 Feb.J Clin Pharmacol. 2014 Feb;54(2):179-88. doi: 10.1002/jcph.244. Epub 2014 Jan...

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Effects of combined netupitant and palonosetron (NEPA), a cancer supportive care antiemetic, on the ECG of healthy subjects: an ICH E14 thorough QT trial.

Science 21. November 2022

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First published in SpringerPlus on 2014 Jul.Springerplus. 2014 Jul 29;3:389. doi: 10.1186/2193-1801-3-389. eCollection 2014. Authors: Spinelli T, Moresino C, Baumann...

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Pharmacokinetics and pharmacodynamics of ponesimod, a selective S1P1 receptor modulator, in the first-in-human study.

Science 15. November 2022

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First published in British Journal of Clinical Pharmacology on 2013 Dec.Br J Clin Pharmacol. 2013 Dec;76(6):888-96. doi: 10.1111/bcp.12129. Authors: Brossard...

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Inhalation of a dry powder ciprofloxacin formulation in healthy subjects: a phase I study.

Science 10. November 2022

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First published in Clinical Drug Investigation on 2013 Jun.Clin Drug Investig. 2013 Jun;33(6):419-27. doi: 10.1007/s40261-013-0082-0 Authors: Stass H, Nagelschmitz J,...

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Single-dose pharmacokinetics, safety, and tolerability of albinterferon alfa-2b in subjects with end-stage renal disease on hemodialysis compared to those in matched healthy volunteers.

Science 10. November 2022

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First published in Antimicrobal Agents and Chemotherapy on 2011 Feb.Antimicrob Agents Chemother. 2011 Feb;55(2):473-7. doi: 10.1128/AAC.00626-10. Authors: Serra DB, Sun...

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Macitentan: entry-into-humans study with a new endothelin receptor antagonist.

Science 10. November 2022

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First published in European Journal of Clinical Pharmacology on 2011 Oct.Eur J Clin Pharmacol. 2011 Oct;67(10):977-84. doi: 10.1007/s00228-011-1043-2. Authors: Sidharta...

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Pharmacokinetics of serelaxin in patients with severe renal impairment or end-stage renal disease requiring hemodialysis: A single-dose, open-label, parallel-group study.

Science 10. November 2022

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First published in The Journal of Clinical Pharmacology on 2016 Apr.J Clin Pharmacol. 2016 Apr;56(4):474-83. doi: 10.1002/jcph.607. Authors: Dahlke M,...

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