safety Archives - CRS. Experts. Early Phase.

Pharmacokinetics, pharmacodynamics, and safety of BAY 2433334, a novel activated factor XI inhibitor, in healthy volunteers: A randomized phase 1 multiple-dose study.

Science 27. Januar 2023

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Efficacy and safety of canagliflozin over 52 weeks in patients with type 2 diabetes on background metformin and pioglitazone.

Science 21. November 2022

First published in Diabetes, Obesity and Metabolism on 2014 May. Diabetes Obes Metab. 2014 May;16(5):467-77. doi: 10.1111/dom.12273. Epub 2014 Mar...

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Effect of linagliptin compared with glimepiride on postprandial glucose metabolism, islet cell function and vascular function parameters in patients with type 2 diabetes mellitus receiving ongoing metformin treatment.

Science 21. November 2022

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First published in Diabetes Metabolism Research and Reviews on 2014 Oct. Diabetes Metab Res Rev. 2014 Oct;30(7):582-9. doi: 10.1002/dmrr.2525 Authors:...

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Pharmacological profile, efficacy and safety of lixisenatide in type 2 diabetes mellitus.

Science 21. November 2022

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First published in Expert Opinion on Pharmacotherapy on 2013 Nov. Expert Opin Pharmacother. 2013 Nov;14(16):2281-96. doi: 10.1517/14656566.2013.838559. Epub 2013 Oct...

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Pharmacokinetics and safety of teneligliptin in subjects with hepatic impairment.

Science 21. November 2022

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First published in Clinical Pharmacology in Drug Development on 2014 Jul.Clin Pharmacol Drug Dev. 2014 Jul;3(4):290-6. doi: 10.1002/cpharmacodynamicsd.89. Epub 2014...

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Multiple-dose tolerability, pharmacokinetics, and pharmacodynamics of ponesimod, an S1P1 receptor modulator: favorable impact of dose up-titration.

Science 21. November 2022

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First published in The Journal of Clinical Pharmacology on 2014 Feb.J Clin Pharmacol. 2014 Feb;54(2):179-88. doi: 10.1002/jcph.244. Epub 2014 Jan...

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Pharmacokinetics, pharmacodynamics and safety of empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, in subjects with renal impairment.

Science 21. November 2022

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First published in Diabetes, Obesity and Metabolism on 2014 Mar.Diabetes Obes Metab. 2014 Mar;16(3):215-22. doi: 10.1111/dom.12182. Epub 2013 Aug 19....

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Effects of combined netupitant and palonosetron (NEPA), a cancer supportive care antiemetic, on the ECG of healthy subjects: an ICH E14 thorough QT trial.

Science 21. November 2022

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First published in SpringerPlus on 2014 Jul.Springerplus. 2014 Jul 29;3:389. doi: 10.1186/2193-1801-3-389. eCollection 2014. Authors: Spinelli T, Moresino C, Baumann...

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Impact of impaired renal function on the pharmacokinetics of the antiepileptic drug lacosamide.

Science 21. November 2022

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First published in Clinical Pharmacokinetics on 2013 Oct.Clin Pharmacokinet. 2013 Oct;52(10):897-906. doi: 10.1007/s40262-013-0080-7. Authors: Cawello W, Fuhr U, Hering U,...

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Pharmacodynamic characteristics of lixisenatide once daily versus liraglutide once daily in patients with type 2 diabetes insufficiently controlled on metformin.

Science 21. November 2022

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First published in Diabetes, Obesity and Metabolism on 2013 Jul.Diabetes Obes Metab. 2013 Jul;15(7):642-9. doi: 10.1111/dom.12076. Epub 2013 Feb 25....

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