beta cell function Archives - CRS. Experts. Early Phase.

Effects of insulin glargine versus metformin on glycemic variability, microvascular and beta-cell function in early type 2 diabetes.

Science 21. November 2022

First published in Acta Diabetologica in 2013 Aug.Acta Diabetol. 2013 Aug;50(4):587-95. doi: 10.1007/s00592-012-0451-9. Epub 2013 Feb 21. Authors: Pistrosch F,...

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Effect of vildagliptin compared to glimepiride on postprandial proinsulin processing in the β cell of patients with type 2 diabetes mellitus.

Science 21. November 2022

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First published in Diabetes, Obesity and Metabolism in 2013 Jun.Diabetes Obes Metab. 2013 Jun;15(6):576-9. doi: 10.1111/dom.12063. Epub 2013 Feb 6....

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Adding insulin glargine vs. NPH insulin to metformin results in a more efficient postprandial beta-cell protection in individuals with type 2 diabetes.

Science 10. November 2022

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First published in Diabetes, Obesity and Metabolism on 2010 May.Diabetes Obes Metab. 2010 May;12(5):437-41. doi: 10.1111/j.1463-1326.2010.01209.x Authors: Forst T, Larbig...

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Limitations of the HOMA-B score for assessment of beta-cell functionality in interventional trials-results from the PIOglim study.

Science 10. November 2022

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First published in Diabetes Technology & Therapeutics on 2010 Aug.Diabetes Technol Ther. 2010 Aug;12(8):599-604. doi: 10.1089/dia.2010.0019 Authors: Pfützner A, Derwahl...

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Elevated intact proinsulin levels are indicative of Beta-cell dysfunction, insulin resistance, and cardiovascular risk: impact of the antidiabetic agent pioglitazone.

Science 10. November 2022

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First published in Journal of Diabetes Science and Technology on 2011 May.J Diabetes Sci Technol. 2011 May 1;5(3):784-93 Authors: Pfützner...

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Sequential Treatment Escalation with Dapagliflozin and Saxagliptin Improves Beta Cell Function in Type 2 Diabetic Patients on Previous Metformin Treatment: An Exploratory Mechanistic Study.

Science 20. April 2020

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We investigated the effect of sequential treatment escalation with dapagliflozin and saxagliptin on beta cell function in patients with T2DM insufficiently controlled on metformin monotherapy during a hyperglycaemic clamp investigation.

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