First published in European Journal of Endocrinology on 2011 Aug.
Eur J Endocrinol. 2011 Aug;165(2):269-74. doi: 10.1530/EJE-11-0061.
Authors: Sourij H, Schmoelzer I, de Campo A, Tripolt NJ, Stojakovic T, Scharnagl H, Kettler-Schmut E, Forst T, Wascher TC
Design and methods
The mean increase in blood glucose was significantly lower after IA (24.18±16.33 vs 34.92±29.07 mg/dl, P=0.02) compared with HI. Both therapies reduced FFA; however, the mean reduction was significantly higher after IA than after HI (-0.47±0.16 vs -0.35±0.15 μmol/l, P<0.001). The mean increase in intact proinsulin was significantly lower after IA than after HI (10.53±5 vs 15.20±6.83 pmol/l, P<0.001). No differences were observed in the C-peptide levels between the two groups.
In the setting of two consecutive meals, IA reduces lipolysis and proinsulin secretion more effectively than HI.
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