Glycosuria with SGLT-2 inhibitors–a new treatment approach for type 2 diabetes mellitus

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First published in MMW – Fortschritte der Medizin on 2012 Dec.
MMW Fortschr Med. 2012 Dec 17;154 Suppl 4:95-101

Authors: Rosak C, Forst T

Abstract

Background

A new mechanism of action in the form of sodium-glucose co-transporter-(SGLT-)2 inhibitors will be available shortly for the treatment of type 2 diabetic patients.

Method

Overview.

Results and conclusions

Fasting and postprandial blood glucose and HbA(1c) concentrations are indirectly reduced by the inhibition of glucose reabsorption and increased glycosuria. SGLT-2 inhibitors also have a positive impact on body weight and blood pressure of type 2 diabetics. In the available registration trials conducted to date, the SGLT-2 inhibitors appeared overall as a safe class of drugs. The clinical importance of an increased incidence of genital infections–in particular in special patientpopulations–requires further clarification. Long-term trials are currently underway to verify safety and in particular cardiovascular effects of this drug class.