Early fasting glucose measurements can predict later glycaemic response to once weekly dulaglutide.

First published in Diabetic Medicine on 2016 Mar.
Diabet Med. 2016 Mar;33(3):391-4. doi: 10.1111/dme.12833.

Authors: Grunberger G, Forst T, Fernández Landó L, Pechtner V, Shaginian R, Jia N, Gough S

Abstract

Aims

To assess whether early measures of fasting blood glucose predict later glycaemic response with once-weekly dulaglutide in patients with Type 2 diabetes mellitus.

Methods

Post hoc analyses were conducted separately for two phase 3 studies (AWARD-5 and AWARD-1) in patients assigned to once-weekly dulaglutide. Week 2 fasting blood glucose was used as a predictor variable, and glycaemic treatment response was defined by HbA1c response based on a composite efficacy endpoint. The association between fasting blood glucose and the glycaemic response was analysed using chi-square tests.

Results

There was a strong association between fasting blood glucose < 7.9 mmol/l at week 2 and achieving the HbA1c composite efficacy endpoint at week 26 (P < 0.01). Higher fasting blood glucose at week 2, however, did not predict absence of glycaemic response and requires further assessment.

Conclusions

Fasting blood glucose measured at 2 weeks may be an early and useful predictor of glycaemic response to once-weekly dulaglutide treatment.

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