Allergen challenge increases anandamide in bronchoalveolar fluid of patients with allergic asthma.

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First published in Clinical Pharmacology and Therapeutics on 2011 Sep.
Clin Pharmacol Ther. 2011 Sep;90(3):388-91. doi: 10.1038/clpt.2011.94. Epub 2011 Jun 29Clin Pharmacol Ther. 2011 Sep;90(3):388-91. doi: 10.1038/clpt.2011.94.

Authors: Zoerner AA, Stichtenoth DO, Engeli S, Batkai S, Winkler C, Schaumann F, Janke J, Holz O, Krug N, Tsikas D, Jordan J, Hohlfeld JM

Abstract

Preclinical studies suggest that the endocannabinoid anandamide restrains allergic airway obstruction and inflammation. Therefore, we applied saline or allergens via bronchoscopy into different lung segments of patients with allergic asthma. Twenty-four hours later, anandamide concentrations in bronchoalveolar lavage fluids had increased more than fourfold. Anandamide concentrations correlated with severity of airway inflammation. These observations suggest that allergen exposure specifically activates the pulmonary endocannabinoid system (ECS) in patients with allergic asthma.

 
 

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