Slide 1WE ARE EARLY PHASESlide 2TRIAL EXPERTISESlide 3THERAPEUTIC EXPERTISE We are EARLY Phase We do one thing only, and we do it reliably in all shapes and colours – even yours. FIND OUT WHO WE ARE Trial Expertise We deliver reliable research on everything first-in-human. And we do it in every relevant field and in our own clinical facilities. LEARN ABOUT OUR METHODOLOGIES Therapeutic EXPERTISE Our specialised units in 4 locations handle indications that range from cardiovascular to respiratory. SEE OUR EXPERTISE BY INDICATION Science Bioequivalence of macitentan and tadalafil given as fixed-dose combination or single-component tablets in healthy subjects. Science Midazolam microdosing applied in early clinical development for drug-drug interaction assessment. Science The effects of vilaprisan on the pharmacodynamics and pharmacokinetics of a combined oral contraceptive – A randomized controlled trial. Science Safety, pharmacokinetics and pharmacodynamics of BI 705564, a highly selective, covalent inhibitor of Bruton’s tyrosine kinase, in Phase I clinical trials in healthy volunteers. Science A practical approach to the clinical challenges in initiation of basal insulin therapy in people with type 2 diabetes. Science Diabetic Macular Edema in Diabetological Practices. read more in our blog Studies in cooperation with: REACHING OUT IS EASY AND FAST – LET’S TALK Prof. Dr. Thomas Forst Chairman of the Executive Boardlocated at CRS Mannheim LET’S TALK SCIENCE *protected email*+49 621 150 45 – 0 Dr. Marc Hetzel VP & Head of Business Developmentlocated at CRS Management LET’S TALK BUSINESS *protected email*+49 621 150 45 – 0 CRO Leadership Awards 2019 CRS is proud to be recognised again by pharma companies worldwide as a leading CRO with regard to: capabilities, compatibility, quality and reliability. European Biotechnology Guide Find CRS’s company profile in the European Biotechnology Science Industry Guide, volume 9 2019. EcoVadis – CSR Rating Based on the CSR rating by EcoVadis in 2022 CRS has been granted Silver Recognition Level.